Let's be real about it,

radical transformations of mind that bring a sense of permanent equanimity are possible!

How best do we realise this?

It will require lots of training and repetitive mental/attentional exercises, that over time rewire our brain and strengthen particular cognitive faculties and capacities (i.e. concentration, meta-cognition, attentional clarity, NPSs, state/perspective flexibility). With these skills developed and the broadening of our consciousness tool kit, the mind can begin to investigate and remodel its own self-understanding. The result is the apprehension of core qualities of phenomena which scale at the most complex and simplest structures of the mind. With such gnosis, something we may call Nirvana can be realised.